Role of Angiopoietin-1 and 2 as Angiogenic Factors in Women With Abnormal Uterine Bleeding

Human uterus is the principal place where angiogenesis occur every month in physiological setting. Abnormal angiogenesis is associated with abnormal uterine bleeding. Angiogenesis, or vascular growth, is therefore an essential component for growththat occurs in endometrium during every cycle of menses.The Angiopoietin family of growth factors along with VEGF family, mostly VEGF-A which are essential for vascular development are involved in endometrial repair mechanism. Angiopoietin binds to its receptor Tie-2 and induce autophosphorylation of receptor and promotes endothelial cell proliferation and finally vessels formation. The purpose of this study was to evaluatewhether idiopathic excess menstrual bleeding is associated with alteration of circulating angiopoetin-1 as well as angiopoietin-2 in women diagnosed with abnormal uterine bleeding and to correlate with control population. This case-control study was conducted on 120 females aged between 18-52 years with history of bleeding excessively for more than 3 months and 120 controls aged between 19-45. Serum Angiopoietin 1 and 2 were measured by ELISA kit method.